curcumin β glucuronide (Santa Cruz Biotechnology)
Structured Review

Curcumin β Glucuronide, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/curcumin β glucuronide/product/Santa Cruz Biotechnology
Average 90 stars, based on 2 article reviews
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1) Product Images from "Chemopreventive efficacy of oral curcumin: a prodrug hypothesis"
Article Title: Chemopreventive efficacy of oral curcumin: a prodrug hypothesis
Journal: The FASEB Journal
doi: 10.1096/fj.201900166R
Figure Legend Snippet: Concentration‐time profiles of curcumin and its metabolite curcumin glucuronide following a single oral dose of curcumin SMEDDS formulation (100 mg/kg) as determined by LC‐MS/MS. Data are means ± sd (n = 3–4). Plasma concentrations for 4T1 tumor‐bearing mice (A), tumor concentrations for 4T1 tumor‐bearing mice (B), plasma concentrations for TuBo tumor‐bearing mice (C), and tumor concentrations for TuBo tumor‐bearing plasma (D).
Techniques Used: Concentration Assay, Formulation, Liquid Chromatography with Mass Spectroscopy, Clinical Proteomics
Figure Legend Snippet: Concentration‐time profiles of curcumin and its metabolite curcumin glucuronide following a single intravenous dose of curcumin glucuronide (2 mg/kg) as determined by LC‐MS. Data are means ± sd (n = 3–4/group/time point). Plasma concentrations for 4T1 tumor‐bearing mice (A), tumor concentrations for 4T1 tumor‐bearing mice (B), plasma concentrations for TuBo tumor‐bearing mice (C), and tumor concentrations for TuBo tumor‐bearing plasma (D).
Techniques Used: Concentration Assay, Liquid Chromatography with Mass Spectroscopy, Clinical Proteomics
Figure Legend Snippet: Mice bearing orthotopic 4T1 tumors received either a single dose or multiple doses of curcumin SMEDDS formulation daily at 100 mg/kg for 14 d prior to tissue and plasma collection. Data shown are means ± sd (n = 4–5). A) Accumulation of curcumin in the tumor tissue after single and multiple oral doses of curcumin. *P < 0.05 compared with curcumin concentrations after 1 single dose. B) Curcumin concentrations in plasma, tumors, and livers of healthy Balb/c mice and mice bearing orthotopic 4T1 tumors. ***P< 0.001 compared with curcumin concentrations in healthy mammary tissue. C) Curcumin glucuronide concentrations in plasma, tumors, and livers of healthy Balb/c mice and mice bearing orthotopic 4T1 tumors. Plasma concentrations are provided in ng/ml. All tissue concentrations are in ng/g. Conc., concentration. **P< 0.01 compared with liver concentrations in healthy animals.
Techniques Used: Formulation, Clinical Proteomics, Concentration Assay